Inflammatory markers in salt sensitive hypertension

Increased levels of atherosclerosis markers in salt-sensitive hypertension.

BACKGROUND Salt sensitivity in essential hypertension is associated with both endothelial dysfunction and increased cardiovascular risk. We evaluated several serum markers of atherosclerosis and endothelial function in a group of essential hypertensive patients classified on the basis of their salt sensitivity. METHODS Forty-three patients were classified as having salt-sensitive (20 subjects...

Salt Sensitive Hypertension and Orexin

Patients With Salt-Sensitive Hypertension

Twenty-two patients with normal plasma renln and essential hypertension were classified as "salt-sensitive" (SS) (n=9) or "non-salt-sensitive" (NSS) (n=13) from an increase in mean blood pressure with changes in sodium intake from 25 to 250 meq/day. With the high sodium diet, the SS patients gained more weight (/?<0.05), retained more sodium (/><0.05), and had a greater increase in cardiac outp...

Development of Salt-Sensitive Hypertension in Hydronephrosis

Targeting cytokine signaling in salt-sensitive hypertension.

Activated immune cell populations contribute to hypertension in part through inciting damage to the kidney and by provoking inappropriate sodium reabsorption in the nephron. Inflammatory mediators called cytokines produced by T lymphocytes and macrophages act on specific sodium transporters in the kidney, augmenting their activity or expression, with consequent expansion of intravascular fluid ...